Recently, a paper titled " Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review " has been published on Food Science and Human Wellness (doi.org/10.1016/j.fshw.2023.04.034).
Dendrobium species (‘Shihu’ in Chinese) such as D. officinale, D. huoshanense, D. nobile, D. chrysanthum, D. loddigesii, D. moniliforme, D. gratiosissimum, D. candidum and D. caulis are widely used as traditional Chinese medicines/nutraceuticals to control and treat neurodegenerative disorders. These health benefits include but not limited to anti-oxidative stress, anti-inflammation, anti-hypertension, anti-hyperlipidemia, anti-diabetes, immunomodulation, anti-aging, cardioprotection, anti-tumor, and gastrointestinal protection. Notably, the maintenance of brain energy homeostasis by Dendrobium species is related to the above-mentioned biological activities. Brain energy homeostasis is an essential physiological function in maintaining good health. However, the impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolism disorders and related neurodegenerative diseases.
At present, the main active ingredients derived from Dendrobium species are classified as alkaloids, polysaccharides, flavonoids, bibenzyl, and polyphenolic compounds have the effect of improving and preventing the symptoms of neurodegenerative diseases. Therefore, in order to gain deep insights into how Dendrobium species and their active compounds impact on brain pathology. This work reviewed their regulatory roles in brain energy homeostasis include reduce neurotoxicity, alleviate brain injury and neuropathy, and thus prevent neurodegenerative conditions including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease, as well as neuropsychiatric diseases such as depression, epileptic seizures, and anxiety in humans and/or rodents, and focused on their role in the regulation of brain energy homeostasis and the underlying molecular mechanisms. It will provide the basis for the clinical application of Dendrobium species.
This study was funded by the National Key Research and Development Program of China (2018YFC1706105), the National Natural Science Foundation of China (81872961), Key Project at Central Government Level (2060302) and Collaborative Innovation Project of Dendrobium Industrialization Development in Anhui Province.
