Ye-Wang Zhang
PhD, Professor
School of Pharmacy, Jiangsu University
Zhenjiang, 212013, People’s Republic of China
Email: zhangyewang@ujs.edu.cn
Tel/Fax: +86-511-8503-8201
ORCID: 0000-0003-073-0721
His research interests focus on the preparation and applications of industrial biocatalysts, including protein engineering, enzyme and cell immobilization, chemical and genetic modification of proteins. Biocatalysis and biotransformation reactions are also his research fields. He has published more than 80 peer reviewed papers, with a H-index of 25. Now he is serving as the associate editor of Frontiers in Bioengineering and Biotechnology, editorial board of Journal of Microbiology and Biotechnology, and the guest editor of Polymers.
Education
2002.09~2006.03, PhD, Biochemical Engineering, East China University of Science and Technology.
1997.09~2000.06, MS, Biochemical Engineering, Dalian University of Technology.
1993.09~1997.06, BS, Chemical Technology, Wuhan Institute of Chemical Technology.
Work Experience
2006.06 ~ present, Professor, School of Pharmacy, Jiangsu University, China.
2000.07 ~ 2002.08, Engineer, Shijiazhuang Pharmaceutical Co. Ltd., China.
Selected Published papers
1.Jia-Ying Huang, Shen Yu, Rui-Fang Li, Ke-Ke Han, Ye-Wang Zhang*. Fabrication of Fe3O4@SiO2-PDA-Ni2+ magnetic nanoparticles for one-step purification and immobilization of His-tagged glucose dehydrogenase. Process Biochemistry 2023, 128: 106-115. DOI: 10.1016/j.procbio.2023.02.024
2.Xiao-Man Fan#, Li-Jian Zhou#, Jia-Ying Huang, Ye-Wang Zhang*. The structures and applications of microbial chondroitin AC lyase. World Journal of Microbiology and Biotechnology, 2022, 38: 199. DOI: 10.1007/s11274-022-03395-1
3.Wei Wei#, Li-Jian Zhou#, Shue Wang, Zheng Zhang, Jia-Ying Huang, Zhao Zhang, Xue-Jun Zhang, Jie Li, Ye-Wang Zhang*. Katsuwonus pelamis peptide and its complexes protect zebrafish and mice from hyperuricemia through promoting kidney excretion of uric acid and inhibiting liver xanthine oxidase activity. Frontiers in Chemistry, 2022, 10: 924371. DOI: 10.3389/fchem.2022.924371.
4.Xue-Yong Li#, Jia-Ying Huang#, Qiang Zhou, Yuan-Yuan Xu, Prabhu Ponnandy*, Ye-Wang Zhang*. Immobilization of alcohol dehydrogenase, acetaldehyde lyase, and NADH oxidase for cascade enzymatic conversion of ethanol to acetoin. Energies, 2022, 15: 4242. DOI: 10.3390/en15124242.
5.Xiao-Man Fan#, Jia-Ying Huang#, Wei-Wei, Xiao-Min Ling, Wen-Bin Su, Ye-Wang Zhang*. A highly active chondroitin sulfate lyase ABC for enzymatic depolymerization of chondroitin sulfate, Polymers, 2022, 14, 1770. DOI: 10.3390/polym14091770
6.Chen-Yuan Zhu, Fei-Long Li, Ye-Wang Zhang*, Rahul K. Gupta, Sanjay K.S. Patel*, Jung-Kul Lee*. Immobilization techniques for therapeutic enzymes. Polymers. 2022, 14, 1409. DOI: 10.3390/polym14071409.
7.Wen-Bin Su, Chen-Yuan Zhu, Hua-Ping Zhou, Jian Gao, Ye-Wang Zhang*. A single site mutation significantly improves the thermostability and activity of heparinase I from Bacteroides eggerthii. Biocatalysis and Biotransformation. 2022, 40: 226-232. DOI:10.1080/10242422.2021.1976757
8.Chen-Yuan Zhu, Yi-Hao Zhu, Hua-Ping Zhou, Yuan-Yuan Xu, Jian Gao*, Ye-Wang Zhang*. Cloning, expression and characterization of an arabitol dehydrogenase and coupled with NADH oxidase for effectively produce L-xylulose. Preparative Biochemistry and Biotechnology. 2022, 52: 590-597. DOI: 10.1080/10826068.2021.1975299.
9.Xue-Yong Li, Meng-Qiu Xu, Hui Liu, Qiang Zhou, Jian Gao, Ye-Wang Zhang*. Combined cross-linked enzyme aggregates of galactitol dehydrogenase and NADH oxidase for the synthesis of tagatose via in situ cofactor regeneration. Bioprocess and Biosystems Engineering. 2022, 45: 353–364. DOI: 10.1007/s00449-021-02665-w
10.Li-Jian Zhou#, Li-Bin Guo#, Wei Wei, Zhi-Xiang Lv, Ye-Wang Zhang*. A novel chondroitinase AC lyase with broad substrate specificity from Pedobacter rhizosphaerae: Molecular cloning, expression, and characterization. Frontiers in Bioengineering and Biotechnology, 2021, 9: 808872. DOI: 10.3389/fbioe.2021.808872
11.Wei Wei#, Xiao-Man Fan#, Shao-Hui Jia, Xi-Ping Zhang, Xue-Jun Zhang, Zhao Zhang, Jiu-Xun Zhang, Ye-Wang Zhang*. Sea cucumber intestinal peptide induces the apoptosis of MCF-7 cells by inhibiting PI3K/AKT pathway. Frontiers in Nutrition. 2021, 8: 763692. DOI: 10.3389/fnut.2021.763692.
12.Li Wang*, Kai-Ren Zhao, Zhi-Jun Liu, Yi-Bang Zhang, Peng-Fei Liu, Shu-Ying Ye, Ye-Wang Zhang*, Guo-Xi Liang*. An “on-off” signal-switchable electrochemiluminescence biosensor for ultrasensitive detection of dual microRNAs based on DNAzyme-powered DNA walker. Sensors and Actuators B: Chemical. 2021, 348: 130660. DOI: 10.1016/j.snb.2021.130660
13.Wen-Bin Su, Chen-Yuan Zhu, Hua-Ping Zhou, Jian Gao, Ye-Wang Zhang*. A single site mutation significantly improves the thermostability and activity of heparinase I from Bacteroides eggerthii. Biocatalysis and Biotransformation. 2021, 40: 226-232. DOI:10.1080/10242422.2021.1976757
14.Chen-Yuan Zhu, Yi-Hao Zhu, Hua-Ping Zhou, Yuan-Yuan Xu, Jian Gao*, Ye-Wang Zhang*. Cloning, expression and characterization of an arabitol dehydrogenase and coupled with NADH oxidase for effectively produce L-xylulose. Preparative Biochemistry and Biotechnology. 2021, 52: 590-597. DOI: 10.1080/10826068.2021.1975299.
15.Wei Wei#, Shue Wang#, Xue-Jun Zhang, Jiu-Xun Zhang, Zheng-Wang Chen, Jia-Ying Huang, Ye-Wang Zhang*. The effects of mung bean peptide and its’ complexes on the treatment of lead poisoning. Journal of Food Quality. 2021, 2851146. DOI: 10.1155/2021/2851146
16.Qiang Zhou, Jian Gao, Ye-Wang Zhang*. Optimal pH shift of NADH oxidase with a single site-directed mutagenesis. Biotechnology Letters. 2021, 43: 1413-1420. DOI: 10.1007/s10529-021-03129-7
17.Li-Jian Zhou#, Rui-Fang Li#, Xue-Yong Li, Ye-Wang Zhang*. One-step selective affinity purification and immobilization of His-tagged enzyme by recyclable magnetic nanoparticles. Engineering in Life Sciences. 2021, 21: 364-373. DOI: 10.1002/elsc.202000093
18.Li-Bin Guo#, Chen-Yuan Zhu#, Yi-Bei Wu, Xiao-Man Fan, Ye-Wang Zhang*. A novel chondroitin AC lyase from Pedobacter xixiisoli: Cloning, expression, and molecular characterization. Enzyme and Microbial Technology. 2021, 146: 109765. DOI: 10.1016/j.enzmictec.2021.109765
19.Wen-Bin Su#, Fei-Long Li#, Xue-Yong Li, Xiao-Man Fan, Rui-Jiang Liu, Ye-Wang Zhang*. Using galactitol dehydrogenase coupled with water-forming NADH oxidase for efficient enzymatic synthesis of L-tagatose. New Biotechnology, 2021, 62: 18-25. DOI: 10.1016/j.nbt.2021.01.003.
20.Xiao-Man Fan, Jia-Jia Shen, Yuan-Yuan Xu, Jian Gao, Ye-Wang Zhang*. Metabolic integration of azide functionalized glycan on Escherichia coli cell surface for specific covalent immobilization onto magnetic nanoparticles with click chemistry. Bioresource Technology. 2021, 324: 124689. DOI: 10.1016/j.biortech.2021.124689
21.Li-Wei Gao, Hong-Tao Zhu, Cai-Yun Liu, Zhi-Xiang Lv, Xiao-Man Fan, Ye-Wang Zhang*. A highly active heparinase from Bacteroides cellulosilyticus: Cloning, high-level expression, and molecular characterization. PLoS One, 2020, 15 (10): e0240920. DOI: 10.1371/journal.pone.0240920
22.Cai-Yun Liu, Wen-Bin Su, Li-Bin Guo, Ye-Wang Zhang*. Cloning, expression and characterization of a novel heparinase I from Bacteroides eggerthii. Preparative Biochemistry and Biotechnology, 2020, 50: 477-485. DOI: 10.1080/10826068.2019.1709977
23.Fei-Long Li, Wen-Bin Su, Qing-Lan Tao, Liao-Yuan Zhang, Ye-Wang Zhang*. Expression, biochemical characterization and mutation of a novel water forming NADH: FMN oxidoreductase from Lactobacillus rhamnosus. Enzyme and Microbial Technology. 2020, 134: 109464. DOI: 10.1016/j.enzmictec.2019.109464
24.Meng-Qiu Xu#, Fei-Long Li#, Wen-Qian Yu, Rui-Fang Li, Ye-Wang Zhang*. Combined cross-linked enzyme aggregates of NADH oxidase and glycerol dehydrogenase for highly effective in situ cofactor regeneration. International Journal of Biological Macromolecules. 2020, 144: 1013-1021. DOI: 10.1016/j.ijbiomac.2019.09.178
25.Fei-Long Li, Qiang Zhou, Wei Wei, Jian Gao, Ye-Wang Zhang*. Switching the substrate specificity from NAD to NADP by a single mutation of NADH oxidase from Lactobacillus rhamnosus. International Journal of Biological Macromolecules. 2019. 135: 328-336. DOI: 10.1016/j.ijbiomac.2019.05.146
26.Fei-Long Li, Qing-Lan Tao, Cai-Yun Liu, Jian Gao, Ye-Wang Zhang*. Role of introduced surface cysteine of NADH oxidase from Lactobacillus rhamnosus. International Journal of Biological Macromolecules. 2019, 132: 150-156. DOI: 10.1016/j.ijbiomac.2019.03.168
27.Yi-Hao Zhu, Cai-Yun Liu, Sha Cai, Li-Bin Guo, In-Won Kim, Vipin C Kalia*, Jung-Kul Lee*, Ye-Wang Zhang*. Cloning, expression and characterization of a highly active alcohol dehydrogenase for efficient production of (S)-ethyl-4-chloride-3-hydroxybutyrate. Indian Journal of Microbiology, 2019, 59: 225-233. DOI: 10.1007/s12088-019-00795-0
28.Fei-Long Li#, Meng-Yao Zhuang#, Jia-Jia Shen, Xiao-Man Fan, Hyunsoo Choi, Jung-Kul Lee*, Ye-Wang Zhang*. Specific immobilization of recombinant E. coli on mannose functionalized magnetic nanoparticles. Catalysts, 2019, 9: 7. DOI: 10.3390/catal9010007
29.Hui Gao, Dakshinamurthy Sivakumar, Tae-Su Kim, Sanjay K. S. Patel, Vipin C Kalia, In-Won Kim*, Ye-Wang Zhang*, Jung-Kul Lee*. NADH oxidase from Lactobacillus reuteri: a versatile enzyme for oxidized cofactor regeneration. International Journal of Biological Macromolecules. 2019, 123: 629-636. DOI: 10.1016/j.ijbiomac.2018.11.096.
30.Meng-Qiu Xu, Shuang-Shuang Wang, Li-Na Li, Jian Gao*, Ye-Wang Zhang*. Combined cross-linked enzyme aggregates as biocatalysts. Catalysts. 2018, 8: 460. DOI: 10.3390/catal8100460.
31.Jian Gao, Chun-Liu Lu, Yue Wang, Shuang-Shuang Wang, Jia-Jia Shen, Jiu-Xun Zhang, Ye-Wang Zhang*. Rapid immobilization of cellulase onto graphene oxide with a hydrophobic spacer. Catalysts. 2018, 8: 180. DOI: 10.3390/catal8050180
32.Meng-Yao Zhuang#, Xiao-Ping Jiang#, Xiao-Min Ling, Meng-Qiu Xu, Yi-Hao Zhu, Ye-Wang Zhang*. Immobilization of NADH oxidase and glycerol dehydrogenase for enzymatic synthesis of 1,3-dihydroxyacetone with in situ cofactor regeneration. Journal of Chemical Technology and Biotechnology. 2018, 93: 2351-2358. DOI: 10.1002/jctb.5579
33.Fei-Long Li, Ying Shi, Jiu-Xun Zhang, Jian Gao, Ye-Wang Zhang*. Cloning, expression, characterization and homology modeling of a novel H2O-forming NADH oxidase from Streptococcus mutans ATCC 25175. International Journal of Biological Macromolecules. 2018, 113: 1073-1079. DOI: 10.1016/j.ijbiomac.2018.03.016
34.Jian Gao, Ai-Rong Wang, Xiao-Ping Jiang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of glycerol dehydrogenase onto epoxy-nanoparticles. Journal of Nanoscience and Nanotechnology. 2018, 18: 4852-4857. DOI: 10.1166/jnn.2018.15266.
35.Meng-Yao Zhuang, Cong Wang, Meng-Qiu Xu, Xiao-Min Ling, Jia-Jia Shen, Ye-Wang Zhang*. Using concanavalinA as a spacer for immobilization of E. coli onto magnetic nanoparticles. International Journal of Biological Macromolecules. 2017, 104: 63-69. DOI: 10.1016/j.ijbiomac.2017.05.150
36.Guo-Hua Xia, Wei Liu, Xiao-Ping Jiang, Xiang-Yu Wang, Ye-Wang Zhang*, Jianyong Guo. Modification of Fe3O4@SiO2 magnetic nanoparticles for immobilization of lipase. Journal of Nanoscience and Nanotechnology. 2017, 17: 370-376. DOI: 10.1166/jnn.2017.10964
37.Meng-Yao Zhuang, Qian-Liu Zhou, Xiang-Yu Wang, Jun-Xi Zhang, Lan Xue, Ru Wang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of lipase onto dopamine functionalized magnetic nanoparticles. Nanoscience and Nanotechnology Letters, 2016, 8: 251-254. DOI: 10.1166/nnl.2016.2127
38.Xiao-Ping Jiang, Ting-Ting Lu, Cai-Hong Liu, Xiao-Ming Ling, Meng-Yao Zhuang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of alcohol dehydrogenase onto epoxy-functionalized Fe3O4@SiO2 nanoparticles for synthesis of (R)-mandelic acid. International Journal of Biological Macromolecules. 2016, 88: 9-17. DOI: 10.1016/j.ijbiomac.2016.03.031
39.Cai-Hong Liu, Xiao-Qian Li, Xiao-Ping Jiang, Meng-Yao Zhuang, Xiao-Min Ling, Jiu-Xun Zhang, Chun-Hai Bao, Ye-Wang Zhang*. Preparation of functionalized graphene oxide nanocomposites for covalent immobilization of NADH oxidase. Nanoscience and Nanotechnology Letters. 2016, 8: 164-167, DOI: 10.1166/nnl.2016.2102
40.Xiao-Min Ling#, Xiang-Yu Wang#, Ping Ma, Yi Yang, Jie-Mei Qin, Xue-Jun Zhang, Ye-Wang Zhang*. Covalent immobilization of penicillin G acylase onto Fe3O4@Chitosan magnetic particles. Journal of Microbiology and Biotechnology, 2016, 26: 829-836. DOI: 104014/jmb.1511.11052
41.Qing-Lan Tao, Yue Li, Ying Shi, Rui-Jiang Liu, Ye-Wang Zhang*, Jianyong Guo. Application of molecular imprinted magnetic Fe3O4@SiO2 nanoparticles for selective immobilization of cellulase. Journal of Nanoscience and Nanotechnology. 2016, 16：6055-6060. DOI: 10.1166/jnn.2015.10853
42.Ruijiang Liu, Jiawen Fan, Yewang Zhang, Peng Wang, Xiangqian Shen. Immobilization and Characterization of Penicillin G Acylase (PGA) Immobilized on Magnetic Ni0.5Zn0.5Fe2O4 Nanoparticles. Journal of Nanoscience and Nanotechnology. 2016, 16: 182-188. DOI: 10.1166/jnn.2016.10639
43.Ying Shi, Wei Liu, Qing-Lan Tao, Xiao-Ping Jiang, Cai-Hong Liu, Sha Zeng, Ye-Wang Zhang*. Immobilization of lipase by adsorption onto magnetic nanoparticles in organic solvents. Journal of Nanoscience and Nanotechnology. 2016, 16: 601-607 DOI: 10.1166/jnn.2015.10694
44.Xiaoyun Zhang*, Ye-Wang Zhang*, Hongyin Zhang, Qiya Yang, Haiying Wang, Guochao Zhang. Preparation, characterization and antibacterial activity of octenyl succinic anhydride modified inulin. International Journal of Biological Macromolecules. 2015, 78: 79-86. DOI: 10.1016/j.ijbiomac.2015.03.067
45.Xingbo Shi, Suli Dong, Minmin Li, Xiaojun Liu, Yewang Zhang, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong and Hongwei Gai*. Counting quantum dots in aggregates for the detection of biotinylated proteins. Chemical Communications. 2015, 51, 2353-2356. DOI: 10.1039/C4CC02918F
46.Xiang-Yu Wang#, Xiao-Ping Jiang#, Yue Li, Sha Zeng, Ye-Wang Zhang*. Preparation Fe3O4@Chitosan magnetic particles for covalent immobilization of lipase from Thermomyces lanuginosus. International Journal of Biological Macromolecules. 2015, 75: 44-50. DOI: 10.1016/j.ijbiomac.2015.01.020
47.Yue Li, Xiang-Yu Wang, Xiao-Ping Jiang, Jing-Jing Ye, Ye-Wang Zhang*, Xiao-Yun Zhang. Fabrication of graphene oxide decorated with Fe3O4@SiO2 for immobilization of cellulase. Journal of Nanoparticle Research, 2015, 17: 8. DOI: 10.1007/s11051-014-2826-z
48.Yue Li, Xiang-Yu Wang, Rui-Zhuo Zhang, Xiao-Yun Zhang, Xi-Ming Xu, Ye-Wang Zhang*. Molecular imprinting and immobilization of cellulase onto magnetic Fe3O4@SiO2 nanoparticles. Journal of Nanoscience and Nanotechnology. 2014, 14: 2931-2936. DOI:10.1166/jnn.2013.8625
49.Wei Liu, Fang Zhou, Xiao-Yun Zhang, Yue Li, Xiang-Yu Wang, Xi-Ming Xu, Ye-Wang Zhang*. Preparation of magnetic Fe3O4@SiO2 nanoparticles for immobilization of lipase. Journal of Nanoscience and Nanotechnology. 2014, 14: 3068-3072. DOI:10.1166/jnn.2013.8567
50.Jianfeng Wang, Wei Liu, Baoquan Liu, Shengdi Fan, Ye-Wang Zhang*. Analyzing increased fluorescence of single quantum dots on dehydrated agarose by single-molecular imaging. Spectroscopy Letters. 2013, 46: 195-200. DOI: 10.1080/00387010.2012.700544
51.Ye-Wang Zhang, Manish Kumar Tiwarri, Hui Gao, Marimuthu Jeya, Jung-kul Lee*. Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus. Enzyme and Microbial Technology. 2012, 50: 255-262. DOI: 10.1016/j.enzmictec.2012.01.009
52.Qiang Tan, Yewang Zhang, Dongzhi Wei. Characterization and stability of D-amino acid oxidase and catalase within the permeabilized recombinant Pichia pastoris cells. African Journal of Biotechnology. 2011, 10: 19153-19160. DOI: 10.5897/AJB11.554
53.Ye-Wang Zhang, Manish Kumar Tiwarri, Marimuthu Jeya, Jung-kul Lee*. Covalent immobilization of recombinant Rhizobium etli CFN42 xylitol dehydrogenase onto modified silica nanoparticles. Applied Microbiology and Biotechnology. 2011, 90: 499-507. DOI: 10.1007/s00253-011-3094-9
54.Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*. Enhanced activity and stability of L-arabinose isomerase by immobilization on aminopropyl glass. Applied Microbiology and Biotechnology. 2011, 89: 1435-1442. DOI: 10.1007/s00253-010-2966-8
55.Raushan Kumar Singh, Ye-Wang Zhang, Ngoc-Phuong-Thao Nguyen, Marimuthu Jeya, Jung-Kul Lee*. Covalent immobilization of β-1,4-glucosidase from Agaricus arvensis onto functionalized silicon oxide nanoparticles. Applied Microbiology and Biotechnology, 2011, 89: 337-344. DOI: 10.1007/s00253-010-2768-z
56.Ye-Wang Zhang*, Rui-Jiang Liu, Xi-Ming Xu*. One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn2+. Applied Microbiology and Biotechnology, 2010, 88:49-55. DOI: 10.1007/s00253-010-2727-8
57.Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*. L-Ribulose production by an Escherichia coli harboring L-arabinose isomerase from Bacillus licheniformis. Applied Microbiology and Biotechnology, 2010, 87: 1993-1999. DOI: 10.1007/s00253-010-2600-9
58.Ye-Wang Zhang, Ponnandy Prabhu, Jung-Kul Lee*. Alginate immobilization of recombinant Escherichia coli whole cells harboring L-arabinose isomerase for L-ribulose production. Bioprocess and Biosystems Engineering, 2010, 33: 741-748. DOI: 10.1007/s00449-009-0397-7
59.Ye-Wang Zhang, Ponnandy Prabhu, Jung-Kul Lee, In-Won Kim*. Enhanced stability of Bacillus licheniformis L-arabinose isomerase by immobilization with alginate. Preparative Biochemistry and Biotechnology, 2010, 40: 65-75. DOI: 10.1080/10826060903400567
60.Qiang Tan, Yewang Zhang, Qingxun Song, Dongzhi Wei. Single-pot conversion of cephalosporin C to 7-aminocephalosporanic acid in the absence of hydrogen peroxide. World Journal of Microbiology and Biotechnology. 2010, 26: 145-152. DOI: 10.1007/s11274-009-0153-9
61.Shu-Guang Fang, Tan Qiang, Rui-Jiang Liu, Xi-Ming Xu, Ye-Wang Zhang*. Enhanced production of 6-aminopenicillanic acid in aqueous-methyl isobutyl ketone system with immobilized penicillin G acylase. Preparative Biochemistry and Biotechnology. 2010, 40(1):38-45. DOI: 10.1080/10826060903389489
62.Ye-Wang Zhang, Ponnandy Prabhu, Jung-kul Lee*. Immobilization of Bacillus licheniformis L-arabinose isomerase for semi-continuous L-ribulose production. Bioscience, Biotechnology and Biochemistry. 2009, 73: 2234-2239. DOI: 10.1271/bbb.90330
63.Hyung-Moo Jung, Marimuthu Jeya, Sang-Yong Kim, Hee-Jung Moon, Raushan Kumar Singh, Ye-Wang Zhang, Jung-Kul Lee*. Biosynthesis, biotechnological production, and application of teicoplanin: current state and perspectives. Applied Microbiology and Biotechnology, 2009, 84:417-428. DOI: 10.1007/s00253-009-2107-4
64.Marimuthu Jeya, Ye-Wang Zhang, In-Won Kim, Jung-Kul Lee*. Enhanced saccharification of alkali treated rice straw by cellulase of Trametes hirsuta and statistical optimization of hydrolysis condition by RSM. Bioresource Technology, 2009, 100 (21): 5155-5161. DOI: 10.1016/j.biortech.2009.05.040
65.Ye-Wang Zhang, Dongzhi Wei*. Enzymatic preparation of cefaclor with immobilized penicillin acylase. Preparative Biochemistry and Biotechnology. 2008, 38: 136-145. DOI: 10.1080/10826060701884046
66.Ye-Wang Zhang, Shu-Lai Liu, Dong-Zhi Wei*, Rui-Jiang Liu, Xi-Mming Xu. Kinetically controlled synthesis of cefaclor with immobilized penicillin acylase in the presence of organic cosolvents. Chemical and Biochemical Engineering Quarterly. 2008, 22: 349-354.
67.Dengchao Li, Yewang Zhang, Dongzhi Wei*, Qingxun Song, Shiwei Cheng. Enzymatic synthesis cephalexin at high substrates concentration with in situ product removal. Food Technology and Biotechnology. 2008, 46: 461-466
68.Rui Han, Yewang Zhang, Xiuling Dong, Hongwei Gai* and Edward S. Yeung. Spectral imaging of single molecules by transmission grating based epi-fluorescence microscopy. Analytica Chimica Acta.2008, 619: 209-214. DOI: 10.1016/j.aca.2008.05.017
69.Ye-Wang. Zhang, Dong-Zhi Wei*, Dengchao Li, Shulai Liu, Qingxun Song. Optimisation of enzymatic synthesis of cefaclor with in situ product removal and continuous acyl donor feeding. Biocatalysis and Biotransformation. 2007, 25: 59-64. DOI: 10.1080/10242420601141762
70.Yewang Zhang*, Ruijiang Liu, Xiaoyu Wu. The proteolytic systems and heterologous proteins degradation in the methylotrophic yeast Pichia pastoris. Annals of Microbiology. 2007, 37, 553-560. DOI: 10.1007/BF03175354
71.Ye-Wang Zhang, Dengchao Li, Qingxun Song, Dongzhi Wei*. Effects of substrate concentration on the enzymatic synthesis of cefaclor by penicillin acylase with in situ product removal. Chemical and Biochemical Engineering Quarterly. 2006, 20: 183-188.
